2014 Robert L. Sinsheimer Distinguished Lecture in Biology
April 14, 2014
Dr. Joan Brugge obtained her Ph.D. from Baylor College of Medicine, and was a post-doctoral fellow at the University of Colorado, Boulder where her seminal work identifying the cellular homolog of src, the transforming gene of Rous sarcoma virus, launched her remarkable career. Currently, the chairman of the Department of Cell Biology at Harvard Medical School, Dr. Brugge has combined her academic research interests with significant accomplishments in the private sector, spending 5 years as the Scientific Director and Vice President for Research of ARIAD Pharmaceuticals. Throughout these professional appointments, Dr. Brugge’s research focus has never wavered from understanding the molecular mechanisms responsible for tumor development. Her research accomplishments are numerous, including the recent discovery of a novel process, a phenomenon the Brugge lab has called entosis or cell death by invasion, in which a cell is literally enveloped by a neighboring cell. Such new discoveries promise fresh ways forward in the search for strategies to kill cancer cells.